Sphingosine kinase regulation and cardioprotection

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منابع مشابه

Sphingosine kinase regulation and cardioprotection.

Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischaemia or at the onset of reperfusion (pharmacologic pre- or postconditioning) results i...

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Sphingosine kinase: biochemical and cellular regulation and role in disease.

Sphingolipids have emerged as molecules whose metabolism is regulated leading to generation of bioactive products including ceramide, sphingosine, and sphingosine-1-phosphate. The balance between cellular levels of these bioactive products is increasingly recognized to be critical to cell regulation; whereby, ceramide and sphingosine cause apoptosis and growth arrest phenotypes, and sphingosine...

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High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer

Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 i...

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Sphingosine-1-phosphate signals the way for Cx43-mediated cardioprotection.

The onset of coronary occlusion caused by vasospasm, thrombosis, or atherosclerotic plaque rupture produces myocardial ischaemia, and acute myocardial infarction (AMI) can result within minutes. Reperfusion with minimal time lapse is the treatment of choice for AMI, but coronary reperfusion can also enhance myocardial injury and the induction of life-threatening cardiac arrhythmias. In 1986, it...

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Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.

Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell processes, including inhibition of apoptosis and stimulation of cell proliferation. Basal levels of S1P in cells are generally low but can increase rapidly when cells are exposed to various agonists through rapid and transient activation...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2008

ISSN: 0008-6363

DOI: 10.1093/cvr/cvn309